Atrium Medical Corporation Announces First Implant of First-in-Man CINATRA(TM) Voclosporin Coated Coronary Stent Jun 9, 2008
The primary endpoint of the trial is to evaluate the safety and performance of the CINATRA(TM) voclosporin coated coronary stent system and the CINATRA(TM) BMS coronary stent system in patients with de novo coronary artery disease. Patient outcomes, in addition to drug coated stent performance, will be assessed by measuring Late Lumen Loss, in-stent and in-segment lumen loss measurements at six months following implantation. (PR Newswire)
'PLoS ONE' STUDY: A Low Dose of Dietary Resveratrol Partially Mimics Caloric Restriction and Retards Aging Parameters in Mice Jun 4, 2008
In skeletal muscle (), these include the de novo methylase Dnmt3a, the chromodomain helicase DNA binding protein 1 (Chd1), the sirtuin Sirt5, and the SWI/SNF complex members Smarcc1, Smarca4, Smarca5 and Smarca2. The Smarca2 gene encodes Brahma, the key component of the SWI/SNF complex, a master transcriptional switch that directs specific cellular programs and uses ATP hydrolysis to remodel chromatin. (USA Today -- Tech)
Penn State Hershey Transplant Program Uses Assay to Monitor Cell-Mediated Immunity Jun 2, 2008
D. and his colleagues studied the immunosuppression status of 52 patients with post-transplant de novo malignancy, assessing the cell-mediated immunity of patients by taking advantage of the ability of the Cylex immune cell function assay (ImmuKnow(R)) ... Their paper is entitled "Monitoring of immune function for treatment of post-transplant de novo malignancy." The 52 patients included 40 kidney transplants, 10 liver transplants, and two kidney and pancreas transplants. (PR Newswire)
Mutations For 10 Percent Of Schizophrenia Found Jun 1, 2008
One of the new or de novo mutations researchers found in more than one affected individual in this study was a deletion of a region of chromosome 22 ... The researchers plan to extend their screen for additional de novo mutations by using increased resolution scans to study additional families ... Strong association of de novo copy number mutations with sporadic schizophrenia. (Science Daily)
2nd Circuit Holds Magistrates Lack Power to Remand May 31, 2008
Nevertheless, he said he was optimistic that, on remand, Skretny would reach the same result after conducting a more searching de novo review of the magistrate judge's report and recommendation, in part because there are two grounds on which to remand the case to state court -- the lack of consent for removal and a lack of subject matter jurisdiction. Scott C. Allan and John F. Renzulli of the Renzulli Law Firm in White Plains represented Beemiller. (Law.com)
Download 2008 Powered by Seagate; Cities and Lineup Announced Today May 31, 2008
(Logo: ) The lineup and cities are as follows: San Francisco: Los Angeles: Philadelphia: Brand New Brand New The Killers Atmosphere & Atmosphere & Iggy Pop & The Brother Ali Brother Ali Stooges Mute Math Ghostland Observatory Mute Math Yeasayer Mute Math Ghostland M83 Yeasayer Observatory Mates Of State M83 Mates Of State RJD2 Mates Of State The Whigs The Whigs RJD2 Man Man Tapes 'n Tapes Tapes 'n Tapes Louis XIV Cut Copy Caribou The Duke Spirit Datarock Datarock The Airborne Toxic The Duke... (Yahoo! Wire -- Entertainment News)
Epigenetic modification of histone 3 at lysine 9 in sheep zygotes and its relationship with DNA methylation May 29, 2008
Our results suggest that in sheep lower DNA demethylation of paternal genomes is not due to the H3K9 modification and the methylated DNA sustaining in paternal pronucleus does not come from DNA de novo methylation. The complete article is available as a. (BioMed Central)
Isotechnika reports final results of the PROMISE trial May 27, 2008
EDMONTON, May 27 /CNW/ - Isotechnika Inc. (TSX:ISA) today announced positive results from the Phase 2b PROMISE trial which evaluated the Company's lead drug, voclosporin, in de novo kidney transplant patients ... "PROMISE has shown that the efficacy of voclosporin is statistically non-inferior when compared to the market leader, tacrolimus in all three dose groups," stated Dr. Robert Foster, Isotechnika's Chairman "While matching tacrolimus in efficacy, key safety advantages such as a lower... (Canada Newswire)
A novel de novo mutation in the serine-threonine kinase STK11 gene in a Korean patient with Peutz-Jeghers syndrome May 22, 2008
Therefore, it is considered a novel de novo mutation ... The results presented herein enlarge the spectrum of mutations of the STK11 gene by identifying a novel de novo mutation in a PJS patient and further support the hypothesis that STK11 mutations are disease-causing mutations for PJS with or without a positive family history. (BioMed Central)
Sahajanand Medical Technologies PAINT Trial Results Support Safety and Efficacy of the Infinnium and Supralimus Stents May 21, 2008
Ltd. (SMT), Surat, India, leading developer and manufacturer of drug-eluting stents, welcomed the positive results of the prospective, randomized nine months results of PAINT trial (PercutAneous INTervention with biodegradable- polymer based paclitaxel-eluting, sirolimus-eluting, or bare stents for the treatment of de novo coronary lesions) ... Primary investigator, Dr Pedro Lemos of the Heart Institute (InCor) University of Sao Paulo Medical School, Brazil, commented that, "The design of PAINT... (PR Newswire)
Jump In: Pop Music May 18, 2008
De Novo Dahl: This Nashville quintet is all about bringing the fun with its sweet, psychedelia-tinged pop sound. June 7, Middle East Upstairs, 617-931-2000. (Boston Globe)
Eisai's Commitment to Oncology Demonstrated by Clinical Data to be Presented at ASCO Annual Meeting May 16, 2008
About Dacogen Dacogen (decitabine) for Injection was approved by the U.S. Food and Drug Administration on May 2, 2006 and is indicated for treatment of patients with myelodysplastic syndromes (MDS) including previously treated and untreated, de novo and secondary MDS of all French-American-British (FAB) subtypes (refractory anemia, refractory anemia with ringed sideroblasts, refractory anemia with excess blasts, refractory anemia with excess blasts in transformation, chronic myelomonocytic... (PR Newswire)
Coming Soon: The Washington Monument, Brought to You by Samsung May 10, 2008
Saudi Arabia is building a massive university de novo, the King Abdullah University of Science and Technology, which is slated to open in 2009. Last month, KAUST announced a $25 million, five-year deal with Cornell to create a joint center on nanomaterials science and technology, with Cornell professors advising on curricular development. (Slate)
Brookdale Announces First Quarter 2008 Results May 8, 2008
(3) Development capital expenditures primarily relate to the facility expansion and de novo development program. Our debt amortization for the three months ended March 31, 2008 and 2007 was as follows (in thousands): Three Months Ended March 31, 2008 2007 Type Scheduled Debt Amortization $391 $574 Lease Financing Debt Amortization - FMV or no Purchase Option $1,625 $1,296 Lease Financing Debt Amortization - Bargain Purchase Option 2,351 2,064 Total Debt Amortization $4,367 $3,934 Our ancillary... (PR Newswire)
Superior Bancorp May 2, 2008
in the first quarter of 2008 after the company incurred substantial expenses related to its de novo branch expansions ... Overall, the company plans to invest up to $30 million in its de novo branching program. (Birmingham Business Journal, AL)
Whitney Reports First Quarter 2008 Earnings Apr 22, 2008
5 million, compared to the first quarter of 2007 mainly related to the facilities acquired with Signature, de novo branch expansion and the completion of capital projects on storm-damaged facilities. Equipment and data processing expense increased 6%, or. (Primezone Releases)
Home BancShares, Inc. Announces First Quarter 2008 Earnings Apr 17, 2008
The increase is primarily the result of our acquisition of Centennial Bancshares in the first quarter of 2008, de novo expansion, additional costs associated with our efficiency study and with the normal increased cost of doing business ... Presently, the Company is evaluating additional opportunities but has no firm commitments for any additional de novo branch locations. (Primezone Releases)
Unconventional wisdom: Eclipse Bank wraps 'build-it-slowly' philosophy in a posh package akin to upscale retailers Apr 11, 2008
It is the Louisville market's first "de novo," or startup, bank since 1996. To build what they term a full-service community bank, John Pendergrass and his wife, Mitzi Pendergrass, chief operating officer, seem to hold two seemingly contradictory strategies simultaneously. (Louisville Business First, KY)
American Principle Bank Announces: First Quarter 2008 Financial Results Apr 10, 2008
The Bank is a de novo financial institution that opened for business on October 15, 2007. The Bank lost $499 thousand during the first quarter of 2008, primarily due to $305 thousand in provision for loan losses recorded to increase the allowance for loan losses in conjunction with the growth in the Bank's loan portfolio. (PR Newswire)
Chelsea Therapeutics Gains Global Rights to I-3D Portfolio Targeting Autoimmune Disease and Transplant Rejection Apr 8, 2008
Inhibition of DHODH is the rate-limiting step in de novo pyrimidine biosynthesis, which is required for the proliferation of T-cells during clonal expansion. Potential indications for drug candidates in this library include transplant rejection, rheumatoid arthritis, psoriasis and systemic lupus erythematosus (SLE). (Primezone Releases)
Lollapalooza Announces Full Line-Up Apr 8, 2008
The Whigs Manchester Orchestra Foals Uffie The Octopus Project Cadence Weapon Ferras De Novo Dahl Noah and the Whale Margot uclear So and So's K'NAAN Serena Ryder Newton Faulkner. More News. (Exclaim!)
CNBS recycles HomeBanc name Apr 4, 2008
CNBS Financial Group in 2007 to build and grow the de novo bank of the South in Orlando and a proposed savings bank in Lakewood Ranch. The company has grown to include loan-production offices in Tampa, Lake Mary, St. Cloud, Brandon and Largo. (Tampa Bay Business Journal, FL)
Comp plan trashed; Red Wing gains upper hand as judge scuttles local laws Apr 4, 2008
"Local Law #7 of 2007 is not a result of strict compliance with SEQRA, and de novo (new) environmental review is required," he said. In their petition, 1133 Taconic LLC, Wilfred Beam, David Dyal, Thomas Dyal, Maria Fitzgibbon and Raython Merrihew asked for the annulment because the town "adopted the wetlands law without taking a hard look at its environmental impact, and because the town board failed to give proper notice of the negative declaration.". (Pine Plains Register Herald, NY)
Drug Discovery Bottleneck Eliminated With New Protocol Apr 2, 2008
"Our Recomb 2008 paper represents the first demonstration of de novo sequencing of nonribosomal peptides. Without knowing the structure of the original compound, we can determine it," explains computer science professor Pavel Pevzner, the last author on the RECOMB 2008 paper and the director of UCSD's Center for Algorithmic and Systems Biology which is part of the UCSD Division of the California Institute for Telecommunications and Information Technology (Calit2). In their RECOMB 2008 paper, the... (Science Daily)
Tracing autism's roots Apr 2, 2008
Based on family studies, scientists have long characterized autism-linked genes as "heritable." But recent research shows a surprisingly large number of mutations tied to autism are "de novo" glitches that arise spontaneously in children whose parents don't carry them. Such spontaneous mutations have come to light by studying so-called "structural changes" in the genome, which, if DNA's chemical letters were arranged in book form, would consist of largish mistakes such as duplicated and missing... (CNNMoney.com)
Wintrust Financial Corporation to Release First Quarter Earnings on Monday, April 21, 2008 Apr 1, 2008
Such forward-looking statements may be deemed to include, among other things, statements relating to the Company's projected growth, anticipated improvements in earnings, earnings per share and other financial performance measures, and management's long-term performance goals, as well as statements relating to the anticipated effects on financial results of condition from expected developments or events, the Company's business and growth strategies, including anticipated internal growth, plans... (PR Newswire)
UC San Diego researchers eliminate drug discovery bottleneck Mar 31, 2008
Our Recomb 2008 paper represents the first demonstration of de novo sequencing of nonribosomal peptides ... In their RECOMB 2008 paper, the researchers document how they used de novo sequencing to determine the structure of two different nonribosomal peptides ... "De Novo Sequencing of Nonribosomal Peptides," presented at RECOMB 2008 by Nuno Bandeira, Julio Ng, Dario Meluzzi, Pieter Dorrestein and Pavel A. Pevzner from University of California, San Diego, USA; Roger G. Linington from University... (EurekAlert!)
NewYork-Presbyterian/Columbia physician-scientists present at ACC's 57th Annual Scientific Session Mar 29, 2008
The Impact of Mandatory Angiographic Follow-up on the One-Year Clinical and Angiographic Results From Endeavor IV: A Randomized Comparison of the Endeavor Drug (ABT-578) Eluting Stent System vs. Taxus in De Novo Native Coronary Lesions. Dr. Martin B. Leon Associate director of the Center for Interventional Vascular Therapy at NewYork-Presbyterian Hospital/Columbia University Medical Center and professor of medicine at Columbia University College of Physicians and Surgeons. (EurekAlert!)
State's few new banks: Lack of bad loans is a strength Mar 25, 2008
As long as those key objectives are satisfied, then it should do well despite current economic conditions, said Johnson, who owns a commercial brokerage business and a separate real estate auction firm and has been investing in or helping start-ups, also known as de novo banks, for about 30 years ... "The present crop of de novo applicants is composed substantially of bankers and directors in most cases who have done de novo banks before, have been through the process and have a clear... (Atlanta Journal-Constitution -- Business)
Steve Marsh Named CEO of Banking Division for Enterprise Financial Mar 25, 2008
Enterprise Financial operates commercial banking and wealth management businesses in metropolitan St. Louis and Kansas City and a loan production office in Phoenix, Arizona with the intent to establish a de novo Arizona state bank charter in 2008. The Company is primarily focused on serving the needs of privately held businesses, their owner families, executives and professionals. (Primezone Releases)
HealthTronics to buy Advanced Medical Partners Mar 21, 2008
"AMPI has a strong history of growth via the development of de novo partnerships with urologists," says James Whittenburg, CEO of HealthTronics. "This combination adds meaningful development talent to our executive team in addition to enhancing our physician network and diversifying our revenue stream. Furthermore, AMPI is aligned with our core philosophy and mission of improving patient care and practice economics for the Company's physician partners.". (Austin Business Journal, TX)
De Novo banks full of veterans from the old Top Four Mar 21, 2008
Members: Not Registered. for free extra services. (Birmingham Business Journal, AL)
Branch mania Mar 4, 2008
The Birmingham-Hoover metro area's de novo bank branch scene is booming ... Last year, banks opened 102 de novo branches across Alabama and a "considerable amount" of those locations were right here in the Birmingham-Hoover area, Harrison said ... Last month, Anniston-based , a de novo bank that made its debut in August, opened its first Birmingham-area branch at 201 Office Park Drive off of burgeoning U.S. 280. (Birmingham Business Journal, AL)
FDIC doesn't see bank failures surging Mar 2, 2008
"There are some small and in many cases de novo [new] banks that have heavily invested in real estate in locales where prices have fallen. Among the largest banks, the capital ratios remain good and I don't expect any serious problems among the larger banks." "Our problem bank list has 76 institutions, low by historical standards," Andrew Gray, a representative for the FDIC, told MarketWatch. "In 1990, there were close to 1,500 on the list. Typically, the number of failures for a given year does... (MarketWatch)
Today's best bets Mar 1, 2008
Your Connection to the. Web Search powered by YAHOO. (Athens Banner-Herald)
Bernanke Says Inflation, Slowdown Complicate Policy (Update2) Feb 29, 2008
There are, for example, some small, or, in many cases, de novo banks that are heavily invested in real estate in locales where prices have fallen. . (Bloomberg)
Branch mania: Banks find fertile ground in metro area Feb 29, 2008
The Birmingham-Hoover metro area's de novo bank branch scene is booming. Within the last six months, 10 Southeastern-based banks have announced plans or have already established new branches in the local market. (Birmingham Business Journal, AL)
Brookdale Announces Fourth Quarter and Full Year 2007 Results Feb 28, 2008
(3) Development capital expenditures primarily relate to the facility expansion and de novo development program. (4) Represents the impact of converting to accrual based reporting for capital expenditures. (PR Newswire)
This week's best bets Feb 28, 2008
T" Terrell of Dan K Theory on drums, will be playing covers by artists such as Jeff Beck and Pink Floyd and original blues, jazz and rock tunes. Special guest Ralph Roddenbery has been singing, playing and telling stories in the Classic City for more than two decades. Admission is a $10 suggested donation that will benefit Nu i's Space. or (706) 546-8209. BreastFest 3-9 p.m. Saturday, Tasty World Increase breast cancer awareness, honor those whose lives have been touched by the disease and enjoy... (Athens Banner-Herald)
First Sound Bank Declares Five Percent Stock Dividend Feb 26, 2008
"This is consistent with both our long-term goal of enhancing shareholder value and our tradition of continuing to reward loyal shareholders." First Sound Bank was founded in July 2004 with initial oversubscribed investor capital of $20 million -- at the time, the most equity ever raised by a de novo bank in the Northwest. Then, in the fall of 2006, the bank raised another oversubscribed $11 million in capital to fund future expansion in the region. (PR Newswire)
IBC Bank ends 2007 on strong note Feb 26, 2008
IBC officials also say that net income for 2007 and 2006 were both negatively impacted by the company's aggressive de novo branch activity. The company added 70 new branches in 2007 and 2006 as part of a corporate strategy that could help attract new low-cost deposits, increase non-interest income as well as retain current customers. (San Antonio Business Journal, TX)
What are simple ways to judge the efficacy of 5-fluorouracil in colonic neoplasm? Feb 23, 2008
It is the only de novo source of thymidylate, an essential precursor of DNA biosynthesis. In the 5-untranslated region of TS gene, there a unique tandem repeated sequence. (EurekAlert!)
High-Low Agreement Puts Limit on Offer of Judgment, N.J. Court Rules Feb 21, 2008
Reviewing Kane's decision de novo, the appeals court found the high-low agreement was an ambiguous contract to be construed against Westmoreland, who drafted the confirming letter. Entering into a high-low agreement usually means a plaintiff cannot recover more than the agreed "high" and thus can only recover prejudgment interest if it falls within that limit, wrote Appellate Division Judge Susan Reisner, joined by William Gilroy and Michael King. (Law.com)
Vion Pharmaceuticals Pays Interest on 7.75% Convertible Senior Notes Feb 16, 2008
Cloretazine(R) (VNP40101M), a unique alkylating agent, is being evaluated in a pivotal Phase II trial as a single agent in elderly patients with de novo poor-risk acute myelogenous leukemia. Clinical trials of Cloretazine(R) (VNP40101M) as a single agent in small cell lung cancer, with temozolomide in brain tumors, and with stem cell transplantation in advanced hematologic malignancies, are also being conducted. (PR Newswire)
Low Glycemic Eating Feb 15, 2008
In the presence of insulin, these de novo fatty acids can be stored in fat cells, resulting in weight gain. The idea behind low glycemic eating is to reduce the release of insulin from the pancreas. (Suite101.com)
Recurrent Genomic Event Associated with Autism Feb 14, 2008
Specific recurrent de novo events were further evaluated in clinical-testing data from Children's Hospital Boston and in a large population study in Iceland. Results Among the AGRE families, we observed five instances of a de novo deletion of 593 kb on chromosome 16p11 ... We did not identify other regions with similar aggregations of large de novo mutations. (New England Journal of Medicine)
Please sequence my eel Feb 9, 2008
When an individual organism genome can be sequenced de novo and assembled for a few hundred thousand dollars or less we are not quite there yet, but could be in a year or two it makes less and less sense to do this via a centralized mechanism. . (Nature News Service)
Washington University increases fleet of Roche Genome Sequencer FLX Systems Feb 8, 2008
With the longer 400 base pair read lengths, we can start to assemble the genomes using a de novo approach, eliminating the need to remap the sequences to a reference genome that can lead to errors ... Specific applications include de novo sequencing and re-sequencing of genomes, metagenomics, RNA analysis, and targeted sequencing of DNA regions of interest. (EurekAlert! -- Business News)
Case on Augusta petitions to stay in Superior Court Feb 7, 2008
At a conference on Jan. 24, Superior Court Justice Joseph Jabar recommended that the lawsuit be moved directly, or "de novo," to the state Supreme Court. But both parties had to agree to the move. (Courier Publications, ME)
Mountain 1st Bank Reports Record Earnings Feb 6, 2008
About Mountain 1st Bank Established in mid 2004 and headquartered in Hendersonville, NC, Mountain 1st Bank and Trust is one of the fastest growing and most successful de novo community banks in the southeast. With over $600 million in assets, Mountain 1st Bank and Trust's more than 155 employees serve eight counties in western North Carolina through fourteen full service branches. (PR Newswire)
Wachovia's Thompson: bank plans no major acquisitions in 2008 Feb 1, 2008
Thompson said Wednesday his bank will focus on building branches from the ground-up, or what the bank calls "de novo" branches. Since year-end 2002, Wachovia has opened 353 new branches, which contributed to 30 percent of the banks deposit growth in 2007. (Orangeburg Times and Democrat, SC)
Cape Fear Bank Corp. Reports 2007 Year-End and Fourth Quarter Results Feb 1, 2008
Expenses associated with branch expansion accounted for the majority of the increase; three de novo branches were opened over the last twelve months, generating additional expenses in virtually every category. Salaries and benefits rose $1. (Primezone Releases)
Genome-wide Study Shed Lights On Factors That Contribute To DNA Mutations Jan 30, 2008
"Our statistical analysis may be useful in predicting which disease-causing microsatellites are likely to have high rates of de novo mutations," said Makova. De novo mutations are those that occur for the first time in a family. (Science Daily)
Enterprise Financial Reports 14 Percent Increase in Net Income and 3 Percent Increase in Earnings Per Share for 2007 Jan 29, 2008
The Company's Arizona CEO, Jack Barry, is actively recruiting additional team members and local investors/directors to serve the planned de novo bank ... Enterprise Financial operates commercial banking and wealth management businesses in metropolitan St. Louis and Kansas City and a commercial loan production office in Phoenix, Arizona with an intent to open a state de novo bank charter in 2008. (Primezone Releases)
Community bank IPOs go nowhere in down market Jan 28, 2008
"The IPOs and the de novo community banks are looking for the same money. We are stuck in the mud puddle right now, somewhat unfairly, I might add.". The national slowdown in the housing market has given financial stocks and the overall banking industry a black eye. (Philadelphia Business Journal, PA)
Union Bankshares Corporation Reports Net Income Jan 26, 2008
"We continue to undertake initiatives that will create greater long-term shareholder value, but result in a drag on current income growth rates. Our recent branch acquisition, as well as the opening of 3 de novo branches in the last 14 months, is an example of our long term focus. The current demand for deposit growth is exceeding the supply available within our marketplace, which is placing extreme pressure on our margin. In 2008, our challenges will be to continue high levels of credit quality... (PR Newswire)
Gateway Financial Holdings Reports FY 2007 Net Income of $11 Million Up $5.8 Million Over 2006 Earnings Per Share Increase of 89.4 Percent to $0.89 Jan 25, 2008
Three de novo financial centers were added this year, in addition to the six financial centers and loan production office added through The Bank of Richmond acquisition which was completed in June 2007 ... The Bank opened three new de novo financial centers during the second half of 2007, in addition to the six financial centers and a loan production office it acquired with The Bank of Richmond merger. (Primezone Releases)
BancorpSouth Announces Earnings of $0.39 per Diluted Share for Fourth Quarter 2007 Jan 24, 2008
As we also do with de novo expansion, we entered these new markets with a veteran management team who share our focus on providing high quality customer service to retail and small to mid-sized businesses ... "Our continuing commitment to conservative operating philosophies and the strength and diversity of markets across our geographic franchise have reduced its effects on the Company, as evidenced by our solid fourth quarter results. In addition, current conditions do not diminish... (PR Newswire)
Chromosomal Abnormalities Play Substantial Role In Autism Jan 23, 2008
The rate of such de novo changes in the general population is typically less than one percent, Scherer said. The researchers detected 13 regions of the genome with overlapping or recurrent chromosomal changes in unrelated people with autism, suggesting that genes located at these sites may cause or add to the complexity of the condition. (Science Daily)
Martha Dean Joins Wainwright Bank as Executive Manager of Operations Jan 19, 2008
Most recently she was SVP - Chief Operating Officer for Commonwealth National Bank, a de novo Bank in Worcester, MA formed in 2001. Prior to that she held operations positions at Flagship Bank and Guaranty Bank , also in Worcester, MA. Founded in 1987, Wainwright Bank is a leading socially progressive bank headquartered in Boston with assets of over $900 million and 11 branches serving neighborhoods throughout Greater Boston. (PR Newswire)
Working around the Mendelians: A Q&A with Michael Wigler Jan 17, 2008
I think that there should have been more controversy about the implication of these certain mixed de novo mutations and inherited models on other disorders like schizophrenia. I don't think it's really penetrated very far. (Scientific American)
Chromosome Abnormalities Raise Risk for Autism Jan 11, 2008
In most cases, the abnormality on the chromosome was not inherited from a parent but occurred de novo, happening during embryonic development. This means the chances of having another child with autism may be closer to 5 percent, as opposed to 50 percent if the abnormality was inherited, the researchers explained. (MEDLINEplus)
New Light Shed On The Mechanics Of Gene Transcription Jan 10, 2008
"At some point you accumulate enough polymerase that it feeds back, so in a sense you've created a factory de novo" said Lis. "This is, to our knowledge, the first demonstration of Pol II recycling at a specific gene in vivo.". (Science Daily)
Bayhill Therapeutics could raise up to $86.25M in IPO Jan 10, 2008
Investors in the company include North Carolina-based , , CMEA Ventures of San Francisco, De Novo Ventures of Menlo Park, LTD of Taiwan, of San Francisco, Indiana-based , of Menlo Park, Morgenthaler Ventures of Menlo Park, of Taiwan, North Carolina-based , of Taiwan, of Menlo Park and of Palo Alto. The company has asked for the ticker symbol "BHTX.". (San Jose Business Journal)
Arbitration awards, valuation errors to avoid Jan 9, 2008
The possibility of an irrational award, however, has caused some arbitration agreements to include an additional term called a de novo review clause, which allows a court to set aside an arbitration award for errors of fact or law. The problem is that Pennsylvania state and federal court rulings disagree on the question of whether these de novo review clauses are enforceable ... A Pennsylvania federal appellate court says parties can agree to have their awards reviewed de novo, whereas a... (Pittsburgh Post-Gazette, PA)
